Brand name 

USA: Motegrity Europe: Resolor Canada: Resotran

Prucalopride is a medication designed to treat chronic constipation - a health problem characterized by infrequent and difficult passage of stools over a prolonged period, along with a range of other distressing symptoms such as abdominal bloating, flatulence, and even vomiting. 

Traditional treatment options for chronic constipation involve mostly diet and lifestyle changes and/or laxatives.

How Does Prucalopride Work?

Prucalopride is characterized as a 5-HT4 agonist. 

This means that it activates the 5-HT4 receptors for the neurotransmitter serotonin. 

This activation is thought to increase the motility of the intestinal system by increasing peristalsis, or the muscle movements of the intestines that propel stool out of the body, making stools easier to pass and resulting in more frequent bowel movements.