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Product Information

Brand Names
  • ​Premarin


Estrogens are female sex hormones produced by the ovaries. Estrogens are necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.

Premarin Vaginal Cream is used locally in the vaginal area to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

What are the available dosage forms and strengths?

Vaginal cream with applicator

  •  0.625 mg/g

How should you use Premarin Vaginal Cream?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use Premarin vaginal cream exactly as directed.

Premarin Vaginal Cream is usually prescribed for daily use only for the first two weeks of therapy. Afterwards, a maintenance dose of two to three times per week is sufficient for most patients.

Follow your doctor's instructions.

To apply this medication, use only the vaginal applicator provided. After each use, take the applicator apart and clean it with mild soap and warm water. Do not use hot or boiling water.

Store at room temperature away from moisture and heat.

Who should not use Premarin Vaginal Cream?

You should not use Premarin Vaginal Cream if you are allergic to any of its ingredients. You should not use this medicine if you have:

  • undiagnosed vaginal bleeding;

  • liver disease;

  • a bleeding disorder;

  • had a heart attack, a stroke, a blood clot; or

  • cancer of the breast, uterus/cervix, or vagina.

If you will have major surgery, or are pregnant you should not use this medication

Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.

Report any unusual vaginal bleeding right away. This medicine is not approved for use by anyone younger than 18 years old.

What to avoid while using Premarin Vaginal Cream?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using estrogen.

Avoid using other vaginal products without your doctor's advice.

What should I tell my healthcare provider before using Premarin Vaginal Cream?

Tell your doctor if you have ever had : 

  • heart disease; 

  • liver problems, or jaundice caused by pregnancy or taking hormones; 

  • kidney disease;

  • gallbladder disease;

  • epilepsy or other seizure disorder;

  • migraines;

  • lupus;

  • endometriosis or uterine fibroid tumors;

  • hereditary angioedema;

  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous

  • system);

Premarin Vaginal Cream can weaken the latex of a condom, diaphragm, or cervical cap. Talk to your doctor about the best birth control methods to use.

What other medicines interact with Premarin Vaginal Cream?

Please tell your doctor or pharmacist if you are using or have recently used any other medicines, including medicines obtained without a prescription, herbal medicines or other natural products.

However, Premarin Vaginal Cream is used for a local treatment in the vagina and is not likely to affect other medicines.

Premarin Vaginal Cream may affect other vaginally applied treatments.

What are the possible side effects of Premarin Vaginal Cream?

Get emergency medical help if you have ​signs of an allergic reaction:​ hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

  • signs of a stroke--sudden numbness or weakness(especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;

  • swelling or tenderness in your stomach;

  • jaundice (yellowing of the skin or eyes);

  • memory problems, confusion, unusual behavior;

  • unusual vaginal bleeding, pelvic pain;

  • a lump in your breast; or

Common side effects may include:

  • headache;

  • flushing (warmth, redness, or tingly feeling);

  • breast tenderness; or

  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

What happens if I overdose?

If you have used more Conjugated Estrogens Vaginal than you should, talk to a doctor or pharmacist immediately.

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, seek emergency medical attention.

Where can I get more information about Premarin Vaginal Cream?

If you have any questions about buying discount ​Premarin Vaginal Cream​ or any other prescription products online, you can contact us.

Could not find your medication? Call us!


For many products we offer a lower per unit cost when you purchase larger quantities. If your quantity is larger than what is available on this website, please contact us directly.


Brand-name and generic products are therapeutically equivalent.


Whatever source country you choose, your product will take about the same number of days to arrive.

Discreet Packaging

Your order for Premarin Vaginal Cream will be shipped in discreet packaging so whether the item is shipped to your home or work no one will know the contents of the shipment until opened.

Delivery Timetable

Average regular delivery time:10 days from our Canadian online pharmacy.

Delivery times for Premarin Vaginal Cream do vary depending on the location of the dispensary. The reason deliveries take time is primarily due to customs procedures that need to be completed prior to allowing our packages to enter the United States. Expedited and tracked delivery services are available from our Canadian online dispensary. Please speak to one of our online pharmacy service representatives if you have any questions about delivery times for your order.

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